Archive for the ‘HGH Publications’ Category
In this section you will find the latest human growth hormone publications, research and medical papers concerning HGH.
You can view all the latest medical news and research papers conducted on human growth hormone.
Growth Hormone Treatment in Growth Hormone-Deficient Adults
Growth Hormone Treatment in Growth Hormone-Deficient Adults
Effects on Exercise Performance
R. C. Cuneo, F. Salomon, C. M. Wiles, R. Hesp and P. H. Sonksen
Division of Medicine, United Medical School, Guy’s Hospital, London., United Kingdom.
Growth hormone (GH) treatment in adults with GH deficiency increases lean body mass and thigh muscle cross-sectional area. The functional significance of this was examined by incremental cycle ergometry in 24 GH-deficient adults treated in a double-blind placebo-controlled trial with recombinant DNA human GH (rhGH) for 6 mo (0.07 U/kg body wt daily). Compared with placebo, the rhGH group increased mean maximal O2 uptake (VO2max) (+406 +/- 71 vs. +133 +/- 84 ml/min; P = 0.016) and maximal power output (+24.6 +/- 4.3 vs. +9.7 +/- 4.8 W; P = 0.047), without differences in maximal heart rate or ventilation.
Forced expiratory volume in 1 s, vital capacity, and corrected CO gas transfer were within normal limits and did not change with treatment. Mean predicted VO2max, based on height and age, increased from 78.9 to 96.0% in the rhGH group (compared with 78.5 and 85.0% for placebo; P = 0.036).
The anaerobic ventilatory threshold increased in the rhGH group (+159 +/- 39 vs. +1 +/- 51 ml/min; P = 0.02). The improvement in VO2max was noted when expressed per kilogram body weight but not lean body mass or thigh muscle area.
We conclude that rhGH treatment in adults with GH deficiency improves and normalizes maximal exercise performance and improves submaximal exercise performance and that these changes are related to increases in lean body mass and muscle mass. Improved cardiac output may also contribute to the effect of rhGH on exercise performance.
Source
http://jap.physiology.org/cgi/content/abstract/70/2/695
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The Effects of Growth Hormone on Athletic Performance, HGH
Systematic Review: The Effects of Growth Hormone on Athletic Performance
Abstract
44 articles describing 27 study samples met inclusion criteria; 303 participants received growth hormone, representing 13.3 person-years of treatment.
Participants were young (mean age, 27 years [SD, 3]), lean (mean body mass index, 24 kg/m2 [SD, 2]), and physically fit (mean maximum oxygen uptake, 51 mL/kg of body weight per minute [SD, 8]). Growth hormone dosage (mean, 36 µg/kg per day [SD, 21]) and treatment duration (mean, 20 days [SD, 18] for studies giving growth hormone for >1 day) varied.
Lean body mass increased in growth hormone recipients compared with participants who did not receive growth hormone (increase, 2.1 kg [95% CI, 1.3 to 2.9 kg]), but strength and exercise capacity did not seem to improve.
Lactate levels during exercise were statistically significantly higher in 2 of 3 studies that evaluated this outcome. Growth hormone–treated participants more frequently experienced soft tissue edema and fatigue than did those not treated with growth hormone.
Source
http://www.annals.org/content/148/10/747.abstract
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Growth Hormone Treatment, GH Treatment, Controlled Study
Growth Hormone Treatment Prevents Loss of Lean Mass after Bariatric Surgery in Morbidly Obese Patients: Results of a Pilot, Open, Prospective, Randomized, Controlled Study
Silvia Savastano, Carolina Di Somma, Luigi Angrisani, Francesco Orio, Salvatore Longobardi, Gaetano Lombardi and Annamaria Colao
Department of Molecular and Clinical Endocrinology and Oncology (S.S., C.D.S., F.O., G.L., A.C.), Division of Endocrinology, University Federico II of Naples, 80131 Naples, Italy; Department of Surgery (L.A.), S. Giovanni Bosco Hospital of Naples, 80144 Naples, Italy; Endocrinology University Parthenope Naples (F.O.), 80133 Naples, Italy; and Department of Medical Affairs Merck-Serono Italia (S.L.), 00176 Rome, Italy
Address all correspondence and requests for reprints to: Annamaria Colao, M.D., Ph.D., Department of Molecular & Clinical Endocrinology and Oncology, “Federico II” University of Naples, via S. Pansini 5, 80131 Naples, Italy. E-mail: colao@unina.it.
Context: The loss of lean body mass (LBM) negatively influences the outcome in bariatric surgery. Impaired GH secretion is frequent in obese patients.
Objective: Our objective was to investigate if GH treatment prevents LBM loss in the early postoperative period.
Design: This was an open, prospective, randomized, and controlled study.
Patients: A total of 24 women (body mass index: 44.4 ± 7.6 kg/m2, aged 36.8 ± 11.7 yr) undergoing laparoscopic-adjustable silicone gastric banding (LASGB) and with GH deficiency after LASGB was included in the study.
Treatment Protocol: Group A (n = 12) included a standardized diet regimen and exercise program plus recombinant human GH (0.5 ± 0.13 mg every day), and group B (n = 12) included a standardized diet regimen and exercise program. The follow-up duration was 6 months.
Results: The excess of body weight loss did not differ between groups A and B after 3 and 6 months. At 3 months, LBM loss was lower (P < 0.0001) and fat mass (FM) loss was higher (P = 0.02) in group A than group B. At 3 and 6 months, appendicular skeletal muscle mass loss was lower (P = 0.000) in group A than group B. At 3 (P = 0.0003 and 0.0005, respectively) and 6 months (P < 0.0001 and 0.0002, respectively), the percent changes of FM and lean body mass were significantly higher in group A than group B. In both groups fasting and postglucose area under the plasma concentration-time curve insulin significantly reduced. The homeostasis model assessment of insulin and insulin sensitivity indexes and total to high-density lipoprotein cholesterol ratio improved only in group A.
Conclusions: GH treatment for 6 months after LASGB reduces loss in LBM and appendicular skeletal muscle mass during a standardized program of low-calorie diet and physical exercise program, with improvement of lipid profile and without a deterioration of glucose tolerance.
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